Gender Differences in Schizophrenia: A Comprehensive Review
Event Type
Research Presentation
Location
Dana Science Building, 2nd floor
Start Date
24-4-2026 1:00 PM
End Date
24-4-2026 2:30 PM
Description
This review synthesizes research on gender differences in schizophrenia across age of onset, symptom presentation, course of illness, biological mechanisms, substance use, and social functioning. Evidence suggests that men experience earlier onset, worse premorbid functioning, more severe negative symptoms, and poorer social functioning. Women displayed later and bimodal onset patterns, stronger affective symptoms, and better social functioning, with their less severe course of illness associated with estrogen's neuroprotective effects. These gender differences contribute to distinct clinical trajectories and treatment needs. This paper argues for the development of gender-specific interventions, including estrogen-based pharmacological interventions for women, and targeted behavioral therapies for men focusing on social skills, substance use, and treatment adherence. Integrating gender-specific considerations in treatment is essential for improving long-term outcomes and creating effective care.
Gender Differences in Schizophrenia: A Comprehensive Review
Dana Science Building, 2nd floor
This review synthesizes research on gender differences in schizophrenia across age of onset, symptom presentation, course of illness, biological mechanisms, substance use, and social functioning. Evidence suggests that men experience earlier onset, worse premorbid functioning, more severe negative symptoms, and poorer social functioning. Women displayed later and bimodal onset patterns, stronger affective symptoms, and better social functioning, with their less severe course of illness associated with estrogen's neuroprotective effects. These gender differences contribute to distinct clinical trajectories and treatment needs. This paper argues for the development of gender-specific interventions, including estrogen-based pharmacological interventions for women, and targeted behavioral therapies for men focusing on social skills, substance use, and treatment adherence. Integrating gender-specific considerations in treatment is essential for improving long-term outcomes and creating effective care.
Comments
Under the direction of Dr. Caroline Mann.