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Event Type
Research Presentation
Academic Department
Chemistry
Location
Dana Science Building, 2nd floor
Start Date
14-4-2023 1:30 PM
End Date
14-4-2023 3:00 PM
Description
One of the most significant challenges in the construction of carbohydrate libraries is controlling the stereoselectivity of newly formed glycosidic linkage. Although a number of impressive advances in this field have been made over the last few decades, some methods achieve high stereoselectivity but very modern yield and vice versa. The central theme of this work is to develop a new method to achieve highly stereoselective glycosylation products starting from a mixture of two enantiomers via dynamic kinetic resolution. We aim to apply our method for the construction of libraries of stereo-defined glycoconjugates. Moreover, mechanistic studies of our method will provide valuable insights into the factors which determine stereocontrol in glycosylation reactions.
Stereoselective Glycosylation via Dynamic Kinetic Resolution
Dana Science Building, 2nd floor
One of the most significant challenges in the construction of carbohydrate libraries is controlling the stereoselectivity of newly formed glycosidic linkage. Although a number of impressive advances in this field have been made over the last few decades, some methods achieve high stereoselectivity but very modern yield and vice versa. The central theme of this work is to develop a new method to achieve highly stereoselective glycosylation products starting from a mixture of two enantiomers via dynamic kinetic resolution. We aim to apply our method for the construction of libraries of stereo-defined glycoconjugates. Moreover, mechanistic studies of our method will provide valuable insights into the factors which determine stereocontrol in glycosylation reactions.
Comments
Under the direction of Dr. Son Hong Nguyen